Highly regio- and enantio-selective deacylation of carbocyclic 3',5'- di-O-acyloxetanocins by lipases

Nobuya Katagiri, Yoshihiro Morishita, Masahiko Yamaguchi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Carbocyclic (-)-3',5'-di-O-acyloxetanocin A and T were hydrolysed by lipase MY to give the corresponding carbocyclic (-)-3'-O-acyloxetanocins with high regioselectivity. Carbocyclic (±)-3',5'-di-O-acetyloxetanocin A was deacetylated by lipase MY to form the corresponding (±)-3'-O- acetyloxetanocin A with high regioselectivity but with low enantioselectivity whereas the compound when treated with lipase type XIII gave carbocyclic (- )-5'-O-acetyloxetanocin A with high regio- and enantio-selectivity.

Original languageEnglish
Pages (from-to)2613-2616
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number17
DOIs
Publication statusPublished - 1998 Apr 23

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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