Highly potent PDE4 inhibitors with therapeutic potential

Hiroshi Ochiai; Tazumi Ohtani; Akiharu Ishida; Kensuke Kusumi; Masashi Kato; Hiroshi Kohno; Katuya Kishikawa; Takaaki Obata; Hisao Nakai; Masaaki Toda

doi:10.1016/j.bmcl.2003.09.087

Highly potent PDE4 inhibitors with therapeutic potential

Hiroshi Ochiai, Tazumi Ohtani, Akiharu Ishida, Kensuke Kusumi, Masashi Kato, Hiroshi Kohno, Katuya Kishikawa, Takaaki Obata, Hisao Nakai, Masaaki Toda

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo™ 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2003.09.087
Publication status	Published - 2004 Jan 5
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2003.09.087

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author = "Hiroshi Ochiai and Tazumi Ohtani and Akiharu Ishida and Kensuke Kusumi and Masashi Kato and Hiroshi Kohno and Katuya Kishikawa and Takaaki Obata and Hisao Nakai and Masaaki Toda",

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AU - Ochiai, Hiroshi

AU - Ohtani, Tazumi

AU - Ishida, Akiharu

AU - Kusumi, Kensuke

AU - Kato, Masashi

AU - Kohno, Hiroshi

AU - Kishikawa, Katuya

AU - Obata, Takaaki

AU - Nakai, Hisao

AU - Toda, Masaaki

PY - 2004/1/5

Y1 - 2004/1/5

N2 - Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo™ 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

AB - Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo™ 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

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JF - Bioorganic and Medicinal Chemistry Letters

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IS - 1

ER -

Highly potent PDE4 inhibitors with therapeutic potential

Abstract

ASJC Scopus subject areas

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