Highly potent PDE4 inhibitors with therapeutic potential

Hiroshi Ochiai; Tazumi Ohtani; Akiharu Ishida; Kensuke Kusumi; Masashi Kato; Hiroshi Kohno; Katuya Kishikawa; Takaaki Obata; Hisao Nakai; Masaaki Toda

doi:10.1016/j.bmcl.2003.09.087

Highly potent PDE4 inhibitors with therapeutic potential

Hiroshi Ochiai, Tazumi Ohtani, Akiharu Ishida, Kensuke Kusumi, Masashi Kato, Hiroshi Kohno, Katuya Kishikawa, Takaaki Obata, Hisao Nakai, Masaaki Toda

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo™ 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2003.09.087
Publication status	Published - 2004 Jan 5
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Highly potent PDE4 inhibitors with therapeutic potential. / Ochiai, Hiroshi; Ohtani, Tazumi; Ishida, Akiharu; Kusumi, Kensuke; Kato, Masashi; Kohno, Hiroshi; Kishikawa, Katuya; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 1, 05.01.2004, p. 207-210.

Research output: Contribution to journal › Article › peer-review

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AU - Nakai, Hisao

AU - Toda, Masaaki

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