Highly potent PDE4 inhibitors with therapeutic potential

Hiroshi Ochiai; Tazumi Ohtani; Akiharu Ishida; Kensuke Kusumi; Masashi Kato; Hiroshi Kohno; Katuya Kishikawa; Takaaki Obata; Hisao Nakai; Masaaki Toda

doi:10.1016/j.bmcl.2003.09.087

Highly potent PDE4 inhibitors with therapeutic potential

Hiroshi Ochiai, Tazumi Ohtani, Akiharu Ishida, Kensuke Kusumi, Masashi Kato, Hiroshi Kohno, Katuya Kishikawa, Takaaki Obata, Hisao Nakai, Masaaki Toda

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo™ 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2003.09.087
Publication status	Published - 2004 Jan 5
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2003.09.087

Cite this

Highly potent PDE4 inhibitors with therapeutic potential. / Ochiai, Hiroshi; Ohtani, Tazumi; Ishida, Akiharu; Kusumi, Kensuke; Kato, Masashi; Kohno, Hiroshi; Kishikawa, Katuya; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 1, 05.01.2004, p. 207-210.

Research output: Contribution to journal › Article › peer-review

@article{3d921fd052ec4296a3144a476376f658,

title = "Highly potent PDE4 inhibitors with therapeutic potential",

abstract = "Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo{\texttrademark} 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.",

author = "Hiroshi Ochiai and Tazumi Ohtani and Akiharu Ishida and Kensuke Kusumi and Masashi Kato and Hiroshi Kohno and Katuya Kishikawa and Takaaki Obata and Hisao Nakai and Masaaki Toda",

year = "2004",

month = jan,

day = "5",

doi = "10.1016/j.bmcl.2003.09.087",

language = "English",

volume = "14",

pages = "207--210",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "1",

}

TY - JOUR

T1 - Highly potent PDE4 inhibitors with therapeutic potential

AU - Ochiai, Hiroshi

AU - Ohtani, Tazumi

AU - Ishida, Akiharu

AU - Kusumi, Kensuke

AU - Kato, Masashi

AU - Kohno, Hiroshi

AU - Kishikawa, Katuya

AU - Obata, Takaaki

AU - Nakai, Hisao

AU - Toda, Masaaki

PY - 2004/1/5

Y1 - 2004/1/5

N2 - Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo™ 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

AB - Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo™ 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

UR - http://www.scopus.com/inward/record.url?scp=0348147636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0348147636&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2003.09.087

DO - 10.1016/j.bmcl.2003.09.087

M3 - Article

C2 - 14684329

AN - SCOPUS:0348147636

VL - 14

SP - 207

EP - 210

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 1

ER -

Highly potent PDE4 inhibitors with therapeutic potential

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this