Highly enantioselective organocatalytic oxidative kinetic resolution of secondary alcohols using chirally Modified AZADOs

Masaki Tomizawa, Masatoshi Shibuya, Yoshiharu Iwabuchi

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

A highly enantioselective organocatalytic oxidative kinetic resolution (OKR) of racemic secondary alcohols has been accomplished using asymmetric organocatalysis. A panel of chirally modified 2-azaadamantane N-oxyls (AZADOs) exhibit superior catalytic activity and high enantioselectivity, allowing us to obtain optically active secondary alcohols with a krel value up to 82.2.

Original languageEnglish
Pages (from-to)1828-1831
Number of pages4
JournalOrganic letters
Volume11
Issue number8
DOIs
Publication statusPublished - 2009 Apr 16

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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