Highly Enantioselective Hydrogenation of (E)-β-(Acylamino)acrylates Catalyzed by Rh(I)-Complexes of Electron-Rich P-Chirogenic Diphosphines

Masaya Yasutake, Ilya D. Gridnev, Natsuka Higashi, Tsuneo Imamoto

Research output: Contribution to journalArticlepeer-review

112 Citations (Scopus)

Abstract

(matrix presented) Excellent enantioselectivities up to 99.7% were achieved in the hydrogenation of (E)-β-(acylamino)acrylates by the use of Rh(I)-complexes of electron-rich diphosphines, t-Bu-BisP* and t-Bu-MiniPHOS. Low-temperature NMR experiments testify that monohydrides with β-carbon atom of the substrate bound to rhodium are involved in the catalytic cycle.

Original languageEnglish
Pages (from-to)1701-1704
Number of pages4
JournalOrganic letters
Volume3
Issue number11
DOIs
Publication statusPublished - 2001 May 31
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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