Abstract
2-Alkenyl- and 2-vinyl-5-pyrimidyl alkanols are highly enantioselective asymmetric autocatalysts with significant amplification of enantiomeric excess in the enantioselective addition of diisopropylzinc to 2-alkenyl- and 2-vinylpyrimidine-5-carbaldehydes. Consecutive asymmetric autocatalysis starting from 7% ee increases the ee of pyrimidyl alkanol up to 99% without the need for any other chiral auxillary.
| Original language | English |
|---|---|
| Pages (from-to) | 166-168 |
| Number of pages | 3 |
| Journal | Chirality |
| Volume | 14 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 2002 Feb 11 |
Keywords
- Addition
- Aldehyde
- Alkylation
- Dialkylzinc
- Enantioselective synthesis
ASJC Scopus subject areas
- Analytical Chemistry
- Catalysis
- Pharmacology
- Drug Discovery
- Spectroscopy
- Organic Chemistry