Abstract
2-Alkenyl- and 2-vinyl-5-pyrimidyl alkanols are highly enantioselective asymmetric autocatalysts with significant amplification of enantiomeric excess in the enantioselective addition of diisopropylzinc to 2-alkenyl- and 2-vinylpyrimidine-5-carbaldehydes. Consecutive asymmetric autocatalysis starting from 7% ee increases the ee of pyrimidyl alkanol up to 99% without the need for any other chiral auxillary.
Original language | English |
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Pages (from-to) | 166-168 |
Number of pages | 3 |
Journal | Chirality |
Volume | 14 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - 2002 Feb 11 |
Keywords
- Addition
- Aldehyde
- Alkylation
- Dialkylzinc
- Enantioselective synthesis
ASJC Scopus subject areas
- Analytical Chemistry
- Catalysis
- Pharmacology
- Drug Discovery
- Spectroscopy
- Organic Chemistry