Abstract
Chiral crystals of sodium chlorate and sodium bromate induced highly enantioselective organic synthesis in combination with asymmetric autocatalysis. (S)-5-Pyrimidyl alkanols with up to 98% ee were obtained in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehydes in the presence of d-sodium chlorate. On the other hand, (R)-5-pyrimidyl alkanols with up to 98% ee were obtained for the corresponding reaction in the presence of l-sodium chlorate. Chiral crystals of d- and l-sodium bromate were also found to work as chiral initiators.
Original language | English |
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Pages (from-to) | 209-214 |
Number of pages | 6 |
Journal | Journal of Molecular Catalysis A: Chemical |
Volume | 216 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2004 Jul 12 |
Keywords
- Asymmetric autocatalysis
- Asymmetric synthesis
- Crystals
- Enantiomorphism
- Surface
ASJC Scopus subject areas
- Catalysis
- Process Chemistry and Technology
- Physical and Theoretical Chemistry