Highly enantiodifferentiating site of human serum albumin for mediating photocyclodimerization of 2-anthracenecarboxylate elucidated by site-specific inhibition/quenching with xenon

Masaki Nishijima, Tamara C.S. Pace, Cornelia Bohne, Tadashi Mori, Yoshihisa Inoue, Takehiko Wada

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Complementary to the previous assignment of the first, second, and fourth binding sites of human serum albumin (HSA) for 2-anthracenecarboxylate (AC) and the subsequent mediation of AC photocyclodimerization, the site-specific inhibition of the enantiodifferentiation by xenon allowed us to assign the remaining third and fifth AC-binding sites to subdomains IB and IIIB, respectively. This study reveals a clearer picture of the binding and photochirogenic behavior of HSA and further expands the scope of bio-supramolecular photochirogenesis.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalJournal of Photochemistry and Photobiology A: Chemistry
Volume331
DOIs
Publication statusPublished - 2016 Dec 1

Keywords

  • 2-Anthracenecarboxylate
  • Human serum albumin
  • Photochirogenesis
  • Photocyclodimerization
  • Xenon

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Physics and Astronomy(all)

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