TY - JOUR
T1 - Highly efficient cavitation-enhanced heating with dual-frequency ultrasound exposure in high-Intensity focused ultrasound treatment
AU - Sasaki, Hiroshi
AU - Yasuda, Jun
AU - Takagi, Ryo
AU - Miyashita, Takuya
AU - Goto, Kota
AU - Yoshizawa, Shin
AU - Umemura, Shin Ichiro
PY - 2014/7
Y1 - 2014/7
N2 - High-Intensity focused ultrasound (HIFU) treatment is a noninvasive therapy for malignant as well as benign tumors. In this method, the ultrasound is generated outside the body and focused to the target tissue. Therefore, physical and mental stresses on the patient are minimal. A drawback of HIFU therapy is the long treatment time for a large tumor owing to a small therapeutic volume by a single exposure. Enhancing the heating effect of ultrasound by cavitation bubbles may solve this problem. They are generated by high-Intensity ultrasound exposure and can convert the acoustic energy into heat at a high efficiency. In this study, we combined "dual-frequency ultrasound exposure" for the efficient generation and expansion of a cavitation bubble cloud, and "multiple-triggered HIFU" for the efficient enhancement of ultrasonic heating. The result suggests that the newly proposed combined method is more efficient than the conventional triggered HIFU method.
AB - High-Intensity focused ultrasound (HIFU) treatment is a noninvasive therapy for malignant as well as benign tumors. In this method, the ultrasound is generated outside the body and focused to the target tissue. Therefore, physical and mental stresses on the patient are minimal. A drawback of HIFU therapy is the long treatment time for a large tumor owing to a small therapeutic volume by a single exposure. Enhancing the heating effect of ultrasound by cavitation bubbles may solve this problem. They are generated by high-Intensity ultrasound exposure and can convert the acoustic energy into heat at a high efficiency. In this study, we combined "dual-frequency ultrasound exposure" for the efficient generation and expansion of a cavitation bubble cloud, and "multiple-triggered HIFU" for the efficient enhancement of ultrasonic heating. The result suggests that the newly proposed combined method is more efficient than the conventional triggered HIFU method.
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U2 - 10.7567/JJAP.53.07KF11
DO - 10.7567/JJAP.53.07KF11
M3 - Article
AN - SCOPUS:84903689675
VL - 53
JO - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes
JF - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes
SN - 0021-4922
IS - 7 SPEC. ISSUE
M1 - 07KF11
ER -