Highly chemoselective reduction of imines using a AuNPore/PhMe2SiH/water system and its application to reductive amination

Balaram S. Takale, Shanmou Tao, Xiaoqiang Yu, Xiujuan Feng, Tienan Jin, Ming Bao, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Abstract An unusually strong affinity of unsupported nanoporous gold (AuNPore) towards aldimines and ketimines has been demonstrated. By using PhMe2SiH and water as a hydrogen source and AuNPore as a catalyst, ketimines and aldimines can be reduced to the corresponding amines in high chemical yields under mild conditions. This system was also applied to the reductive amination of aldehydes and ketones.

Original languageEnglish
Article number26172
Pages (from-to)7154-7158
Number of pages5
Issue number39
Publication statusPublished - 2015 Aug 17


  • Amine
  • Heterogeneous catalysis
  • Imine
  • Nanoporous gold
  • Reductive amination

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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