High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "One-Pot" operations

Hayato Ishikawa; Takaki Suzuki; Yujiro Hayashi

doi:10.1002/anie.200804883

High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "One-Pot" operations

Hayato Ishikawa, Takaki Suzuki, Yujiro Hayashi

Research output: Contribution to journal › Article › peer-review

348 Citations (Scopus)

Abstract

Taking shortcuts: A remarkably short and high-yielding asymmetric total synthesis of (-)-oseltamivir takes advantage of organocatalysis and single-pot domino operations. The target, known as the drug Tamiflu, is prepared efficiently in a short time, and also its derivatives can be synthesized effectively.

Original language	English
Pages (from-to)	1304-1307
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	7
DOIs	https://doi.org/10.1002/anie.200804883
Publication status	Published - 2009 Feb 2
Externally published	Yes

Keywords

Antiviral agents
Domino reactions
Organocatalysis
Oseltamivir
Tamiflu

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200804883

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High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "One-Pot" operations

Abstract

Keywords

ASJC Scopus subject areas

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