High-topography surface functionalization based on parylene-C peel-off for patterned cell growth

Florian Larramendy, Daniela Serien, Shotaro Yoshida, Laurent Jalabert, Shoji Takeuchi, Oliver Paul

Research output: Contribution to journalConference article

1 Citation (Scopus)

Abstract

This paper introduces a new technique for patterning functionalization layers on substrates with high-topography. The method is based on a parylene-C template shaped by a structured, sacrificial photoresist layer and attached to the substrate where functionalization is not intended. After photoresist removal and surface functionalization, the parylene layer is peeled off, leaving all areas initially covered by the sacrificial polymer functionalized. The technique has several advantages: (i) In contrast to microcontact printing, it allows surfaces with complex topographies to be functionalized; (ii) complex functionalization patterns are possible; (iii) the parylene structure can be reutilized. We successfully demonstrate the technique with the guided growth of neuron-like PC12 cells on honeycomb-shaped protein patterns on micropillars and microwells. The range and limits of the technique are analyzed and discussed in detail.

Original languageEnglish
Article number7050955
Pages (from-to)328-331
Number of pages4
JournalProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2015-February
Issue numberFebruary
DOIs
Publication statusPublished - 2015 Feb 26
Externally publishedYes
Event2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015 - Estoril, Portugal
Duration: 2015 Jan 182015 Jan 22

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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