High-throughput synthesis of combinatorial libraries based on natural products

Takayuki Doi, Hiroshi Tanaka, Takashi Takahashi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Solid-phase syntheses of combinatorial libraries based on natural products, such as, (i) vitamin D3, (ii) macrosphelide A, (iii) aurilide, (iv) aeruginosin 298-A, (v) trisaccharides, (vi) clavulone, (vii) 15-deoxyPGJ 2, (viii) phlorizin, (ix) naltrindole, and (x) norbinaltorphimine are described. The highly convergent synthetic strategies that enable the high-throughput syntheses of their derivatives are also outlined.

Original languageEnglish
Pages (from-to)795-804
Number of pages10
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume65
Issue number8
DOIs
Publication statusPublished - 2007 Aug
Externally publishedYes

Keywords

  • Alkaloids
  • Combinatorial synthesis
  • Natural products
  • Oligosaccharides
  • Peptides
  • Solid-phase synthesis
  • Split & mix method
  • Steroids
  • Terpenes

ASJC Scopus subject areas

  • Organic Chemistry

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