High throughput biological analysis using multi-bit magnetic digital planar tags

B. Hong, J. R. Jeong, J. Llandro, T. J. Hayward, A. Ionescu, T. Trypiniotis, T. Mitrelias, K. P. Kopper, S. J. Steinmuller, J. A.C. Bland

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)

Abstract

We report a new magnetic labelling technology for high-throughput biomolecular identification and DNA sequencing. Planar multi-bit magnetic tags have been designed and fabricated, which comprise a magnetic barcode formed by an ensemble of micron-sized thin film Ni80Fe20 bars encapsulated in SU8. We show that by using a globally applied magnetic field and magneto-optical Kerr microscopy the magnetic elements in the multi-bit magnetic tags can be addressed individually and encoded/decoded remotely. The critical steps needed to show the feasibility of this technology are demonstrated, including fabrication, flow transport, remote writing and reading, and successful functionalization of the tags as verified by fluorescence detection. This approach is ideal for encoding information on tags in microfluidic flow or suspension, for such applications as labelling of chemical precursors during drug synthesis and combinatorial library-based high-throughput multiplexed bioassays.

Original languageEnglish
Title of host publicationBiomagnetism and Magnetic Biosystems Based on Molecular Recognition Processes
Pages74-81
Number of pages8
DOIs
Publication statusPublished - 2008
EventBiomagnetism and Magnetic Biosystems Based on Molecular Recognition Processes - Sant Feliu de Guixols, Spain
Duration: 2007 Sep 222007 Sep 27

Publication series

NameAIP Conference Proceedings
Volume1025
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

OtherBiomagnetism and Magnetic Biosystems Based on Molecular Recognition Processes
CountrySpain
CitySant Feliu de Guixols
Period07/9/2207/9/27

Keywords

  • High-throughput bioassay
  • Magnetic tagging
  • Remote encoding

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Hong, B., Jeong, J. R., Llandro, J., Hayward, T. J., Ionescu, A., Trypiniotis, T., Mitrelias, T., Kopper, K. P., Steinmuller, S. J., & Bland, J. A. C. (2008). High throughput biological analysis using multi-bit magnetic digital planar tags. In Biomagnetism and Magnetic Biosystems Based on Molecular Recognition Processes (pp. 74-81). (AIP Conference Proceedings; Vol. 1025). https://doi.org/10.1063/1.2956820