High serum erythropoietin level is associated with smaller infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention

Shigeto Namiuchi, Yutaka Kagaya, Jun Ohta, Nobuyuki Shiba, Masafumi Sugi, Masayoshi Oikawa, Hiroyuki Kunii, Hidetsugu Yamao, Nobuo Komatsu, Mitsuru Yui, Hiroko Tada, Masahito Sakuma, Jun Watanabe, Toshikatsu Ichihara, Kunio Shirato

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)

Abstract

OBJECTIVES: We investigated whether a higher serum erythropoietin (EPO) level in patients with acute myocardial infarction (MI) subjected to successful primary percutaneous coronary intervention (PCI) can predict a smaller infarct size determined by creatine kinase (CK) release. BACKGROUND: Erythropoietin has been shown to protect cardiomyocytes from ischemia-reperfusion injury in rodents. METHODS: We prospectively studied 101 patients with first MI who received successful primary PCI within 12 h from the onset of MI. Blood samples were collected to examine the serum EPO level after the primary PCI and within 24 h from the onset of MI. RESULTS: The peak CK level and cumulative CK release were significantly lower in the above-median EPO group than in the below-median EPO group. Thrombolysis In Myocardial Infarction (TIMI) grades and collateral grades before PCI, infarct-related coronary arteries, time to the successful reperfusion from the onset of MI, and serum creatinine levels were similar in the two EPO groups. A stepwise multiple regression analysis revealed that the absolute serum EPO level (mU/ml) as well as TIMI grades after PCI and preinfarction angina was an independent predictor for the cumulative CK release. CONCLUSIONS: These data suggest that a high endogenous EPO level can predict a smaller infarct size in patients with acute MI subjected to successful primary PCI. This might be attributed to the potentially protective effect of endogenous EPO against ischemia-reperfusion injury in humans.

Original languageEnglish
Pages (from-to)1406-1412
Number of pages7
JournalJournal of the American College of Cardiology
Volume45
Issue number9
DOIs
Publication statusPublished - 2005 May 3

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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