Abstract
In this study, we demonstrate the use of surface plasmon interaction between Au nanoparticles (GPs) and a Au thin film for enhancement of surface plasmon resonance (SPR) spectroscopy sensing for DNA hybridization. In situ DNA hybridization with a Au-nanoparticle-attached probe DNA (DNA-GP) monolayer is monitored by SPR spectroscopy, and the results reveal that the DNA-GP allows detection of unlabeled target DNA with the large dynamic range of 1 pM to 10 μM.
Original language | English |
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Journal | Japanese Journal of Applied Physics, Part 2: Letters |
Volume | 44 |
Issue number | 50-52 |
DOIs | |
Publication status | Published - 2005 Dec 16 |
Keywords
- Au nanopartiole
- DNA hybridization
- In situ
- Label-free
- SPR
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)