High salt concentrations increase permeability through ompc channels of escherichia coli

Seiji Kojima, Hiroshi Nikaido

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Background: OmpC porin is less permeable than OmpF, but there is little difference in channel size.

Results: There are more charged residues in the OmpC channel, and mutating them or increasing ionic strength made it more permeable and OmpF-like.

Conclusion: Charged residues produce the low permeability of OmpC.

Significance: OmpC, produced in a high ionic strength environment, has properties optimized for this environment.

Original languageEnglish
Pages (from-to)26464-26473
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
Publication statusPublished - 2014 Sep 19
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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