High prevalence of serum anti-NH2-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome

Akio Kikuchi, Makoto Yoneda, Takafumi Hasegawa, Akiko Matsunaga, Masamichi Ikawa, Takaaki Nakamura, Michinori Ezura, Toru Baba, Naoto Sugeno, Shun Ishiyama, Yasunari Nakamoto, Atsushi Takeda, Masashi Aoki

Research output: Contribution to journalArticlepeer-review


Background: Hashimoto’s encephalopathy with serum anti-NH2-terminal of α-enolase (NAE) antibodies occasionally displays clinical symptoms such as cerebellar ataxia and parkinsonism. We studied the frequency of anti-NAE antibodies in patients with Parkinson-plus syndrome. Methods: We examined the positive rates of anti-NAE antibodies in 47 patients with multiple system atrophy (MSA), 29 patients with Parkinson’s disease (PD), eight patients with corticobasal syndrome (CBS), and 18 patients with progressive supranuclear palsy (PSP) using conventional immunoblot analysis. Results: Positive anti-NAE antibody rates of 31.9%, 10.3%, 50.0%, and 11.1% were reported in the MSA, PD, CBS, and PSP patients, respectively. The duration from onset to a wheelchair-bound state in seropositive MSA patients tended to be shorter than that in seronegative MSA patients. Conclusions: Anti-NAE antibodies are detected in some patients clinically diagnosed with MSA and CBS. Although its pathophysiological significance remains uncertain, serum anti-NAE antibodies might represent a prognostic marker in the clinical course of MSA.

Original languageEnglish
Pages (from-to)4291-4295
Number of pages5
JournalJournal of neurology
Issue number11
Publication statusPublished - 2021 Nov
Externally publishedYes


  • Anti-NH-terminal of α-enolase antibodies
  • Corticobasal syndrome
  • Multiple system atrophy
  • Parkinson’s disease
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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