An unexpected reaction sequence occurs when simple nitroarenes and the readily available enamine 4-(cyclohex-1-en-1-yl)morpholine are placed under high pressure. This one-pot transformation leads to the generation of highly substituted compounds and presents different advantages such as (1) a rapid increase of molecular complexity through converting simple, cheap, and seldom exploited starting materials into polycyclic structures never described before, (2) the absence of chemical catalysts, (3) a very low energy input.
- High pressure
- Nitroaromatic compounds
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry