High Ki-67 labeling index in human colorectal cancer with microsatellite instability

Sho Takagi, Shinji Kumagai, Yoshitaka Kinouchi, Nobuo Hiwatashi, Fumio Nagashima, Seiichi Takahashi, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: In the present study, we examined the relationships between microsatellite status and Ki-67 labeling index, a proliferative marker, in colorectal cancers in order to clarify the common biological profiles of familial and sporadic cases of MSI (microsatellite inability) -positive tumors. Patients and Methods: Seventy-eight invasive colorectal carcinomas were studied. Five microsatellite loci were analyzed by polymerase chain reaction, while Ki-67 was studied by immunohistochemistry. Results: The MSI was found in 15 (19.2%) of the 78 tumors, and the Ki-67 labeling index was significantly higher in the 15 MSI-positive tumors than that in the 15 MSI-negative ones (p = 0.0181). Moreover, the Ki-67 labeling index was significantly higher in the 7 tumors with MSI at more than 2 loci (MSI-H; high-frequency MSI) than that in the MSI-negative ones (p = 0.0082). Conclusion: The present study demonstrates that colorectal cancers with MSI show high Ki-67 labeling index irrespective of hereditary or nonfamilial cancer types, suggesting their common biological aspects distinct from MSI-negative ones.

Original languageEnglish
Pages (from-to)3241-3244
Number of pages4
JournalAnticancer research
Volume22
Issue number6 A
Publication statusPublished - 2002 Nov

Keywords

  • Cell cycle
  • Colorectal cancer
  • Ki-67
  • Microsatellite instability
  • Proliferation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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