High incidence of GalNAc disialosyl lactotetraosylceramide in metastatic renal cell carcinoma

Ryo Maruyama, Seiichi Saito, Vladimir Bilim, Noboru Hara, Toshiyuki Itoi, Kazutoshi Yamana, Tsutomu Nishiyama, Yoichi Arai, Kota Takahashi, Yoshihiko Tomita

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background: In renal cell carcinoma (RCC), glycosphingolipids monosialosyl globopentaosylceramide (MSGb5) and GalNAc disialosyl lactotetraosylceramide (GalNAcDSLc4) were shown to be predictors of metastasis. Here we extended the research using a larger cohort of patients with a longer follow-up period, and reevaluate their relationship to malignant potential, metastasis and prognosis in patients with RCC. Patients and Methods: MSGbS and GalNAcDSLc4 were examined in 114 primary RCCs by immunohistochemical method on cryostat sections. Results: GalNAcDSLc4 was detected in 13.2% of RCCs and was associated with a significantly higher incidence of metastasis at the time of primary visit (60.0% vs. 31.3%, p=0.0419) as well as de novo metastasis during follow-up (33.3% vs. 14.7%), and a shorter survival (p=0.0399). MSGb5 was detected in 51.8% of tumors and was not related to clinocopathological characteristics or survival. Conclusion: RCC patients with tumors positive for GalNAcDSLc4 are at higher risk of metastasis at the time of diagnosis and during follow-up.

Original languageEnglish
Pages (from-to)4345-4350
Number of pages6
JournalAnticancer research
Volume27
Issue number6 C
Publication statusPublished - 2007 Nov

Keywords

  • Glycosphingolipids
  • Metastasis
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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