High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

Norihiko Akamatsu; Yasuaki Yamada; Hiroo Hasegawa; Koki Makabe; Ryutaro Asano; Izumi Kumagai; Ken Murata; Yoshitaka Imaizumi; Kunihiro Tsukasaki; Kazuto Tsuruda; Kazuyuki Sugahara; Sunao Atogami; Katsunori Yanagihara; Shimeru Kamihira

doi:10.1016/j.canlet.2007.06.001

High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

Norihiko Akamatsu, Yasuaki Yamada, Hiroo Hasegawa, Koki Makabe, Ryutaro Asano, Izumi Kumagai, Ken Murata, Yoshitaka Imaizumi, Kunihiro Tsukasaki, Kazuto Tsuruda, Kazuyuki Sugahara, Sunao Atogami, Katsunori Yanagihara, Shimeru Kamihira

ENG - Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.

Original language	English
Pages (from-to)	196-206
Number of pages	11
Journal	Cancer Letters
Volume	256
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2007.06.001
Publication status	Published - 2007 Oct 28

Keywords

Apoptosis
Bcl-2
Follicular lymphoma
IL-21

ASJC Scopus subject areas

Oncology
Cancer Research

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High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. / Akamatsu, Norihiko; Yamada, Yasuaki; Hasegawa, Hiroo; Makabe, Koki; Asano, Ryutaro; Kumagai, Izumi; Murata, Ken; Imaizumi, Yoshitaka; Tsukasaki, Kunihiro; Tsuruda, Kazuto; Sugahara, Kazuyuki; Atogami, Sunao; Yanagihara, Katsunori; Kamihira, Shimeru.

In: Cancer Letters, Vol. 256, No. 2, 28.10.2007, p. 196-206.

Research output: Contribution to journal › Article › peer-review

Akamatsu, Norihiko ; Yamada, Yasuaki ; Hasegawa, Hiroo ; Makabe, Koki ; Asano, Ryutaro ; Kumagai, Izumi ; Murata, Ken ; Imaizumi, Yoshitaka ; Tsukasaki, Kunihiro ; Tsuruda, Kazuto ; Sugahara, Kazuyuki ; Atogami, Sunao ; Yanagihara, Katsunori ; Kamihira, Shimeru. / High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. In: Cancer Letters. 2007 ; Vol. 256, No. 2. pp. 196-206.

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abstract = "We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.",

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AU - Kumagai, Izumi

AU - Murata, Ken

AU - Imaizumi, Yoshitaka

AU - Tsukasaki, Kunihiro

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AU - Sugahara, Kazuyuki

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