Abstract
We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.
Original language | English |
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Pages (from-to) | 196-206 |
Number of pages | 11 |
Journal | Cancer Letters |
Volume | 256 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2007 Oct 28 |
Externally published | Yes |
Keywords
- Apoptosis
- Bcl-2
- Follicular lymphoma
- IL-21
ASJC Scopus subject areas
- Oncology
- Cancer Research