High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

Norihiko Akamatsu; Yasuaki Yamada; Hiroo Hasegawa; Koki Makabe; Ryutaro Asano; Izumi Kumagai; Ken Murata; Yoshitaka Imaizumi; Kunihiro Tsukasaki; Kazuto Tsuruda; Kazuyuki Sugahara; Sunao Atogami; Katsunori Yanagihara; Shimeru Kamihira

doi:10.1016/j.canlet.2007.06.001

High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

Norihiko Akamatsu, Yasuaki Yamada, Hiroo Hasegawa, Koki Makabe, Ryutaro Asano, Izumi Kumagai, Ken Murata, Yoshitaka Imaizumi, Kunihiro Tsukasaki, Kazuto Tsuruda, Kazuyuki Sugahara, Sunao Atogami, Katsunori Yanagihara, Shimeru Kamihira

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.

Original language	English
Pages (from-to)	196-206
Number of pages	11
Journal	Cancer Letters
Volume	256
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2007.06.001
Publication status	Published - 2007 Oct 28
Externally published	Yes

Keywords

Apoptosis
Bcl-2
Follicular lymphoma
IL-21

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2007.06.001

Cite this

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title = "High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma",

abstract = "We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.",

keywords = "Apoptosis, Bcl-2, Follicular lymphoma, IL-21",

author = "Norihiko Akamatsu and Yasuaki Yamada and Hiroo Hasegawa and Koki Makabe and Ryutaro Asano and Izumi Kumagai and Ken Murata and Yoshitaka Imaizumi and Kunihiro Tsukasaki and Kazuto Tsuruda and Kazuyuki Sugahara and Sunao Atogami and Katsunori Yanagihara and Shimeru Kamihira",

year = "2007",

month = oct,

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doi = "10.1016/j.canlet.2007.06.001",

language = "English",

volume = "256",

pages = "196--206",

journal = "Cancer Letters",

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T1 - High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

AU - Akamatsu, Norihiko

AU - Yamada, Yasuaki

AU - Hasegawa, Hiroo

AU - Makabe, Koki

AU - Asano, Ryutaro

AU - Kumagai, Izumi

AU - Murata, Ken

AU - Imaizumi, Yoshitaka

AU - Tsukasaki, Kunihiro

AU - Tsuruda, Kazuto

AU - Sugahara, Kazuyuki

AU - Atogami, Sunao

AU - Yanagihara, Katsunori

AU - Kamihira, Shimeru

PY - 2007/10/28

Y1 - 2007/10/28

N2 - We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.

AB - We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.

KW - Apoptosis

KW - Bcl-2

KW - Follicular lymphoma

KW - IL-21

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DO - 10.1016/j.canlet.2007.06.001

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VL - 256

SP - 196

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JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -

High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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