High-fat diet intake from senescence inhibits the attenuation of cell functions and the degeneration of villi with aging in the small intestine, and inhibits the attenuation of lipid absorption ability in SAMP8 mice

Kazushi Yamamoto, E. Shuang, Hatakeyama Yu, Sakamoto Yu, Tsuyoshi Tsuduki

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    We examined the effect of a high-fat diet from senescence as a means of preventing malnutrition among the elderly. The senescence-accelerated mouse P8 was used and divided into three groups. The 6C group was given a normal diet until 6 months old. The 12N group was given a normal diet until 12 months old. The 12F group was given a normal diet until 6 months old and then a high-fat diet until 12 months old. In the oral fat tolerance test, there was a decrease in area under the curve for serum triacylglycerol level in the 12N group and a significant increase in the 12F group, suggesting that the attenuation of lipid absorption ability with aging was delayed by a high- fat diet from senescence. To examine this mechanism, histological analysis in the small intestine was performed. As a result, the degeneration of villi with aging was inhibited by the high-fat diet. There was also a significant decrease in length of villus in the small intestine in the 12N group and a significant increase in the 12F group. The high-fat diet from senescence inhibited the degeneration of villi with aging in the small intestine, and inhibited the attenuation of lipid absorption ability. andcopy; 2015 JCBN.

    Original languageEnglish
    Pages (from-to)204-211
    Number of pages8
    JournalJournal of Clinical Biochemistry and Nutrition
    Volume57
    Issue number3
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Aging
    • High fat diet
    • Lipid absorption
    • SAMP8
    • Small intestine

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics
    • Clinical Biochemistry

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