High-fat diet intake from senescence inhibits the attenuation of cell functions and the degeneration of villi with aging in the small intestine, and inhibits the attenuation of lipid absorption ability in SAMP8 mice

Kazushi Yamamoto, E. Shuang, Hatakeyama Yu, Sakamoto Yu, Tsuyoshi Tsuduki

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We examined the effect of a high-fat diet from senescence as a means of preventing malnutrition among the elderly. The senescence-accelerated mouse P8 was used and divided into three groups. The 6C group was given a normal diet until 6 months old. The 12N group was given a normal diet until 12 months old. The 12F group was given a normal diet until 6 months old and then a high-fat diet until 12 months old. In the oral fat tolerance test, there was a decrease in area under the curve for serum triacylglycerol level in the 12N group and a significant increase in the 12F group, suggesting that the attenuation of lipid absorption ability with aging was delayed by a high- fat diet from senescence. To examine this mechanism, histological analysis in the small intestine was performed. As a result, the degeneration of villi with aging was inhibited by the high-fat diet. There was also a significant decrease in length of villus in the small intestine in the 12N group and a significant increase in the 12F group. The high-fat diet from senescence inhibited the degeneration of villi with aging in the small intestine, and inhibited the attenuation of lipid absorption ability. andcopy; 2015 JCBN.

Original languageEnglish
Pages (from-to)204-211
Number of pages8
JournalJournal of Clinical Biochemistry and Nutrition
Volume57
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Aging
  • High fat diet
  • Lipid absorption
  • SAMP8
  • Small intestine

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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