High-fat diet intake accelerates aging, increases expression of Hsd11b1, and promotes lipid accumulation in liver of SAMP10 mouse

Taro Honma, Nahoko Shinohara, Junya Ito, Ryo Kijima, Soko Sugawara, Tatsuya Arai, Tsuyoshi Tsuduki, Ikuo Ikeda

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    An understanding of the mechanisms of aging is important for prevention of age-related diseases. In this study, we examined age-dependent changes in lipid metabolism in the senescence-accelerated mouse (SAM)P10 fed a high-fat diet to investigate the effects of high-fat intake and aging. Tissue weights and biological parameters in plasma and liver were measured at 6 and 12 months old in SAMP10 mice fed a high-fat diet. These mice showed marked increases in liver triacylglycerol and plasma insulin levels with intake of a high-fat diet intake and aging. Lipid accumulation in hepatocytes and morphological aberrations and hypertrophy in pancreatic islets were also promoted by a high-fat diet and aging. To investigate the underlying mechanisms, the activities and mRNA levels for enzymes associated with lipid metabolism in liver were measured. The results indicated that the lipid metabolic system was activated by a high-fat diet and aging. Liver mRNA level for hydroxysteroid 11-beta dehydrogenase 1 (Hsd11b1), which exhibit age-dependent increases and promote insulin secretion, was also markedly increased. These results suggest that a high-fat diet accelerated aging in the liver of SAMP10 mice by increasing liver mRNA level for Hsd11b1, increasing insulin secretion, and promoting lipid accumulation in the liver.

    Original languageEnglish
    Pages (from-to)93-103
    Number of pages11
    JournalBiogerontology
    Volume13
    Issue number2
    DOIs
    Publication statusPublished - 2012 Apr

    Keywords

    • Aging
    • High-fat diet
    • Hsd11b1
    • Hyperinsulinemia
    • Lipid metabolism
    • SAMP10

    ASJC Scopus subject areas

    • Ageing
    • Gerontology
    • Geriatrics and Gerontology

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