High efficiency preparation of L-[S-methyl-11C]methionine by on-column [11C]methylation on C18 Sep-Pak

Claudio Pascali, Anna Bogni, Ren Iwata, Donatella Decise, Flavio Crippa, Emilio Bombardieri

    Research output: Contribution to journalArticlepeer-review

    54 Citations (Scopus)


    A novel approach to the synthesis of L-[S-methyl-11C]methionine, (11C]MET) is described which involves a commercial C18 Sep-Pak Plus as a solid-phase support material for the [11C]methylation step. The present method, which uses [11C]CH3I produced by the classical LiAlH4/HI route, supplies [11C]MET ready for injection within 11 min from the end of bombardment (EOB) with a radiochemical yield, decay corrected at EOB, of 78% and a radiochemical purity at the end of synthesis (EOS) higher than 99%. The required setup is extremely simple and easy to automate and can be reset for a further synthesis within few minutes. Moreover, due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation.

    Original languageEnglish
    Pages (from-to)715-724
    Number of pages10
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Issue number8
    Publication statusPublished - 1999 Jan 1


    • On-column reaction
    • PET
    • [C]methionine

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry


    Dive into the research topics of 'High efficiency preparation of L-[S-methyl-11C]methionine by on-column [11C]methylation on C18 Sep-Pak'. Together they form a unique fingerprint.

    Cite this