Abstract
A novel approach to the synthesis of L-[S-methyl-11C]methionine, (11C]MET) is described which involves a commercial C18 Sep-Pak Plus as a solid-phase support material for the [11C]methylation step. The present method, which uses [11C]CH3I produced by the classical LiAlH4/HI route, supplies [11C]MET ready for injection within 11 min from the end of bombardment (EOB) with a radiochemical yield, decay corrected at EOB, of 78% and a radiochemical purity at the end of synthesis (EOS) higher than 99%. The required setup is extremely simple and easy to automate and can be reset for a further synthesis within few minutes. Moreover, due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation.
Original language | English |
---|---|
Pages (from-to) | 715-724 |
Number of pages | 10 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 42 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1999 Jan 1 |
Keywords
- On-column reaction
- PET
- [C]methionine
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry