High CSF neurofilament heavy chain levels in neuromyelitis optica

I. Miyazawa, I. Nakashima, A. Petzold, K. Fujihara, S. Sato, Y. Itoyama

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


The neurofilament heavy chain (NfH), a biomarker of axonal damage in the CSF, was measured in patients with neuromyelitis optica (NMO) and multiple sclerosis (MS). Significantly high CSF NfH levels (>0.73 ng/mL) were found in 6 of 24 (25%) of the patients with NMO but none of the patients with MS (0/24). This finding suggests that axonal damage is more severe in NMO than in MS.

Original languageEnglish
Pages (from-to)865-867
Number of pages3
Issue number11
Publication statusPublished - 2007 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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