High Correlation between Lipid Peroxide Radical and Tumor‐promoter Effect: Suppression of Tumor Promotion in the Epstein‐Barr Virus/B‐Lymphocyte System and Scavenging of Alkyl Peroxide Radicals by Various Vegetable Extracts

Hiroshi Maeda, Takato Katsuki, Takaaki Akaike, Ritsu Yasutake

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We examined the ability of hot‐water extracts of 66 vegetables and plants to suppress tumor promotion, as well as to scavenge lipid peroxide radicals in vitro. To assess the effect against tumor promotion (transformation) in vitro, we used the phorbol myristate acetate/Epstein‐Barr virus/ B‐lymphocyte system. To assess the lipid radical‐scavenging effect, the luminol‐enhanced cliemi‐luminescence method using the tot‐butyl hydroperoxide/heme system was used, which generates more alkyl peroxide radical (ROO·) than alkyl (R·) and alkoxyl <RO) radicals. The results showed a significant correlation between the anti‐tumor‐promoting effect and the lipid radical‐scavenging effect (r=0.82). We found that boiled extracts of green leaves of carrot, crucifers, and beans (black bean, red bean, mung bean, and soybean) had the greatest anti‐tumor‐promoter and radical‐scavenging activities. Cold‐water extracts of vegetables generally exhibited only about 10% or less of the activity of the hot‐water extracts.

Original languageEnglish
Pages (from-to)923-928
Number of pages6
JournalJapanese Journal of Cancer Research
Volume83
Issue number9
DOIs
Publication statusPublished - 1992 Sep
Externally publishedYes

Keywords

  • EA antigen of EB virus extract of vegetable
  • Key words
  • Lipid peroxide radicals
  • Radical scavenger
  • Tumor promoter

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'High Correlation between Lipid Peroxide Radical and Tumor‐promoter Effect: Suppression of Tumor Promotion in the Epstein‐Barr Virus/B‐Lymphocyte System and Scavenging of Alkyl Peroxide Radicals by Various Vegetable Extracts'. Together they form a unique fingerprint.

  • Cite this