High COPD prevalence in patients with liver disease

Yoshiaki Minakata, Hiroki Ueda, Keiichiro Akamatsu, Masae Kanda, Satoru Yanagisawa, Tomohiro Ichikawa, Akira Koarai, Tsunahiko Hirano, Hisatoshi Sugiura, Kazuto Matsunaga, Masakazu Ichinose

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Objective Comorbidities of chronic obstructive pulmonary disease (COPD) have been recognized as an important issue in COPD management. We have reported that patients with liver diseases show a higher prevalence of COPD, but the number of patients with liver diseases was small and the details of liver diseases were not clearly investigated. In this study, we investigated the prevalence of COPD in patients with liver diseases by recruiting a large number of patients, and also investigated was the effect of hepatitis virus infection on COPD prevalence. Patients and Methods Six hundred sixty-six patients were recruited from 9 primary care clinics and three hospitals. All of these patients were aged 40 years or older with chronic diseases and had not been diagnosed as having respiratory diseases. A spirometry was performed without administration of an inhaled bronchodila-tor. Airflow limitation was defined as FEV1/FVC <70%. Underlying diseases were diagnosed by doctors of the clinics or the hospitals. Results Two hundred fifty-six patients had liver diseases, and 410 did not. Of 410 patients without liver diseases, 37 patients (9.0%) were diagnosed as COPD, and of 256 patients with liver diseases, 35 patients (13.8%) were COPD. When the prevalence was analyzed according to smoking, age and gender, liver diseases showed a significantly high odds ratio (2.10, 95%CI 1.23-3.57, p=0.006), but hepatitis virus infection showed a non-significant tendency toward a high odds ratio. Conclusion The patients with liver diseases had a significantly high prevalence of COPD. The presence of liver disease might become a useful predictor for the early detection of COPD.

Original languageEnglish
Pages (from-to)2687-2691
Number of pages5
JournalInternal Medicine
Issue number24
Publication statusPublished - 2010


  • Comorbidity
  • Copd
  • Hepatitis virus
  • Liver disease

ASJC Scopus subject areas

  • Internal Medicine


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