High-calcium exposure to frog heart: A simple model representing hypercalcemia-induced ECG abnormalities

Itsuro Kazama

Research output: Contribution to journalComment/debatepeer-review

4 Citations (Scopus)

Abstract

By simply adding a high concentration of calcium solution to the surface of the bullfrog heart, we reproduced electrocardiogram (ECG) abnormalities representing those observed in hypercalcemia, such as Osborn waves and shortening of the QT interval. The rise in extracellular calcium concentration may have activated the outward potassium currents during phase 3 of the action potential, and thus decreased its duration. In addition to the known decrease in the duration of phase 2, such changes in phase 3 were also likely to contribute to the shortening of the QT interval. The dual recordings of the action potential in cardiomyocytes and the ECG waves enabled us to demonstrate the mechanisms of ECG abnormalities induced by hypercalcemia.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalJournal of Veterinary Medical Science
Volume79
Issue number1
DOIs
Publication statusPublished - 2017 Jan

Keywords

  • Action potential
  • Bullfrog heart
  • Hypercalcemia
  • Osborn waves
  • Shortening of QT interval

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint

Dive into the research topics of 'High-calcium exposure to frog heart: A simple model representing hypercalcemia-induced ECG abnormalities'. Together they form a unique fingerprint.

Cite this