Hg2+-trapping beads: Hg2+-specific recognition through thymine-Hg(II)-thymine base pairing

Mituhiro Kuriyama; Kaichiro Haruta; Takenori Dairaku; Takuya Kawamura; Shoko Kikkawa; Kiyofumi Inamoto; Hirokazu Tsukamoto; Yoshinori Kondo; Hidetaka Torigoe; Itaru Okamoto; Akira Ono; Eugene Hayato Morita; Yoshiyuki Tanaka

doi:10.1248/cpb.c13-00918

Hg²⁺-trapping beads: Hg²⁺-specific recognition through thymine-Hg(II)-thymine base pairing

Mituhiro Kuriyama, Kaichiro Haruta, Takenori Dairaku, Takuya Kawamura, Shoko Kikkawa, Kiyofumi Inamoto, Hirokazu Tsukamoto, Yoshinori Kondo, Hidetaka Torigoe, Itaru Okamoto, Akira Ono, Eugene Hayato Morita, Yoshiyuki Tanaka

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Mercury pollution poses a severe threat to human health. To remove Hg ²⁺ from contaminated water, we synthesized Hg²⁺-trapping beads that include oligo-thymidine functionalities that can form thymine-Hg(II)-thymine base pairs on the solid support. The beads can selectively trap Hg²⁺ even in the presence of other metal cations. More interestingly, Hg²⁺-trapping efficiency was higher in the presence of the co-existing cations. Thus, the developed Hg²⁺- trapping beads can capture Hg²⁺ without affecting the mineral balance of water so much. The Hg²⁺-trapping beads presented here show promise for removing Hg²⁺ from environmental water.

Original language	English
Pages (from-to)	709-712
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	62
Issue number	7
DOIs	https://doi.org/10.1248/cpb.c13-00918
Publication status	Published - 2014 Jul

Keywords

DNA-metal interaction
Mercury removal
Oligonucleotide
Thymine
Thymine-Hg(II)-thymine base pair

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.c13-00918

Fingerprint Dive into the research topics of 'Hg<sup>2+</sup>-trapping beads: Hg<sup>2+</sup>-specific recognition through thymine-Hg(II)-thymine base pairing'. Together they form a unique fingerprint.

Cite this

Hg²⁺-trapping beads : Hg²⁺-specific recognition through thymine-Hg(II)-thymine base pairing. / Kuriyama, Mituhiro; Haruta, Kaichiro; Dairaku, Takenori; Kawamura, Takuya; Kikkawa, Shoko; Inamoto, Kiyofumi; Tsukamoto, Hirokazu; Kondo, Yoshinori; Torigoe, Hidetaka; Okamoto, Itaru; Ono, Akira; Morita, Eugene Hayato; Tanaka, Yoshiyuki.

In: Chemical and Pharmaceutical Bulletin, Vol. 62, No. 7, 07.2014, p. 709-712.

Research output: Contribution to journal › Article › peer-review

Kuriyama, Mituhiro ; Haruta, Kaichiro ; Dairaku, Takenori ; Kawamura, Takuya ; Kikkawa, Shoko ; Inamoto, Kiyofumi ; Tsukamoto, Hirokazu ; Kondo, Yoshinori ; Torigoe, Hidetaka ; Okamoto, Itaru ; Ono, Akira ; Morita, Eugene Hayato ; Tanaka, Yoshiyuki. / Hg²⁺-trapping beads : Hg²⁺-specific recognition through thymine-Hg(II)-thymine base pairing. In: Chemical and Pharmaceutical Bulletin. 2014 ; Vol. 62, No. 7. pp. 709-712.

@article{5bd5c7b1fdd34480a76660237b5a0a8a,

title = "Hg2+-trapping beads: Hg2+-specific recognition through thymine-Hg(II)-thymine base pairing",

abstract = "Mercury pollution poses a severe threat to human health. To remove Hg 2+ from contaminated water, we synthesized Hg2+-trapping beads that include oligo-thymidine functionalities that can form thymine-Hg(II)-thymine base pairs on the solid support. The beads can selectively trap Hg2+ even in the presence of other metal cations. More interestingly, Hg2+-trapping efficiency was higher in the presence of the co-existing cations. Thus, the developed Hg2+- trapping beads can capture Hg2+ without affecting the mineral balance of water so much. The Hg2+-trapping beads presented here show promise for removing Hg2+ from environmental water.",

keywords = "DNA-metal interaction, Mercury removal, Oligonucleotide, Thymine, Thymine-Hg(II)-thymine base pair",

author = "Mituhiro Kuriyama and Kaichiro Haruta and Takenori Dairaku and Takuya Kawamura and Shoko Kikkawa and Kiyofumi Inamoto and Hirokazu Tsukamoto and Yoshinori Kondo and Hidetaka Torigoe and Itaru Okamoto and Akira Ono and Morita, {Eugene Hayato} and Yoshiyuki Tanaka",

year = "2014",

month = jul,

doi = "10.1248/cpb.c13-00918",

language = "English",

volume = "62",

pages = "709--712",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "7",

}

TY - JOUR

T1 - Hg2+-trapping beads

T2 - Hg2+-specific recognition through thymine-Hg(II)-thymine base pairing

AU - Kuriyama, Mituhiro

AU - Haruta, Kaichiro

AU - Dairaku, Takenori

AU - Kawamura, Takuya

AU - Kikkawa, Shoko

AU - Inamoto, Kiyofumi

AU - Tsukamoto, Hirokazu

AU - Kondo, Yoshinori

AU - Torigoe, Hidetaka

AU - Okamoto, Itaru

AU - Ono, Akira

AU - Morita, Eugene Hayato

AU - Tanaka, Yoshiyuki

PY - 2014/7

Y1 - 2014/7

N2 - Mercury pollution poses a severe threat to human health. To remove Hg 2+ from contaminated water, we synthesized Hg2+-trapping beads that include oligo-thymidine functionalities that can form thymine-Hg(II)-thymine base pairs on the solid support. The beads can selectively trap Hg2+ even in the presence of other metal cations. More interestingly, Hg2+-trapping efficiency was higher in the presence of the co-existing cations. Thus, the developed Hg2+- trapping beads can capture Hg2+ without affecting the mineral balance of water so much. The Hg2+-trapping beads presented here show promise for removing Hg2+ from environmental water.

AB - Mercury pollution poses a severe threat to human health. To remove Hg 2+ from contaminated water, we synthesized Hg2+-trapping beads that include oligo-thymidine functionalities that can form thymine-Hg(II)-thymine base pairs on the solid support. The beads can selectively trap Hg2+ even in the presence of other metal cations. More interestingly, Hg2+-trapping efficiency was higher in the presence of the co-existing cations. Thus, the developed Hg2+- trapping beads can capture Hg2+ without affecting the mineral balance of water so much. The Hg2+-trapping beads presented here show promise for removing Hg2+ from environmental water.

KW - DNA-metal interaction

KW - Mercury removal

KW - Oligonucleotide

KW - Thymine

KW - Thymine-Hg(II)-thymine base pair

UR - http://www.scopus.com/inward/record.url?scp=85047688586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047688586&partnerID=8YFLogxK

U2 - 10.1248/cpb.c13-00918

DO - 10.1248/cpb.c13-00918

M3 - Article

C2 - 24990507

AN - SCOPUS:85047688586

VL - 62

SP - 709

EP - 712

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 7

ER -