Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

Takahiro Ugai, Atsushi Minami, Ryuya Fujii, Mizuki Tanaka, Hiroki Oguri, Katsuya Gomi, Hideaki Oikawa

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)

    Abstract

    A unique highly reducing polyketide synthase (HR-PKS) with a reductase domain was identified in a betaenone biosynthetic gene cluster. Successful heterologous expression and characterization of the HR-PKS and trans-acting enoyl reductase (ER) provide insights into the core structure formation with a decalin scaffold and allow reconstitution of the betaenone biosynthetic machinery.

    Original languageEnglish
    Pages (from-to)1878-1881
    Number of pages4
    JournalChemical Communications
    Volume51
    Issue number10
    DOIs
    Publication statusPublished - 2015 Feb 4

    ASJC Scopus subject areas

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

    Fingerprint

    Dive into the research topics of 'Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis'. Together they form a unique fingerprint.

    Cite this