Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis

Takahiro Ugai, Atsushi Minami, Ryuya Fujii, Mizuki Tanaka, Hiroki Oguri, Katsuya Gomi, Hideaki Oikawa

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

A unique highly reducing polyketide synthase (HR-PKS) with a reductase domain was identified in a betaenone biosynthetic gene cluster. Successful heterologous expression and characterization of the HR-PKS and trans-acting enoyl reductase (ER) provide insights into the core structure formation with a decalin scaffold and allow reconstitution of the betaenone biosynthetic machinery.

Original languageEnglish
Pages (from-to)1878-1881
Number of pages4
JournalChemical Communications
Volume51
Issue number10
DOIs
Publication statusPublished - 2015 Feb 4

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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