Heterogeneous distributions of histamine H3, dopamine D1 and D2 receptors in rat brain

Jong Hoon Ryu, Kazuhiko Yanai, Ren Iwata, Tatsuo Ido, Takehiko Watanabe

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

The changes of the histamine H3 and dopamine D1 or D2 receptor binding sites induced by quinolinic acid treatment were studied in order to discriminate the comparative distribution. This treatment resulted in similar decreases in histamine H3 and dopamine D1 receptor binding sites in the striatum and ipsilateral substantia nigra. Dopamine D2 receptor binding sites were relatively well conserved, whereas H3 receptors decreased considerably. These results suggest that histamine H3 and dopamine D1 receptor binding sites are localized on the striatonigral projection neurones which are together sensitive to quinolinic acid, and that the distributional compartment of dopamine D2 receptor binding sites is quite different from those of histamine H3 and dopamine D1 receptors.

Original languageEnglish
Pages (from-to)621-624
Number of pages4
JournalNeuroReport
Volume5
Issue number5
DOIs
Publication statusPublished - 1994 Jan

Keywords

  • Dopamine D1 receptor
  • Dopamine D2 receptor
  • Double labelled autoradiography
  • Histamine H3 receptor
  • Imaging plate
  • Quinolinic acid
  • Striatum
  • Substantia nigra

ASJC Scopus subject areas

  • Neuroscience(all)

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