Heterogeneous Catalytic Reduction of Tertiary Amides with Hydrosilanes Using Unsupported Nanoporous Gold Catalyst

Yuhui Zhao, Sheng Zhang, Yoshinori Yamamoto, Ming Bao, Tienan Jin, Masahiro Terada

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We have demonstrated that the unsupported nanoporous gold (AuNPore) was a green and highly efficient heterogeneous catalyst for the reduction of amides to amines using hydrosilanes as reductants. A variety of tertiary amides with a broad functional groups were reduced to the corresponding tertiary amines in the presence of 2 mol% of AuNPore and PheMe2SiH or (Me2SiH)2O under mild conditions. AuNPore catalyst was recovered by simple filtration and used for twelve times without any loss of catalytic activity. The AuNPore/hydrosilane system was also successfully applied to the hydrosilative reduction of sulfoxides and N-oxides. (Figure presented.).

Original languageEnglish
Pages (from-to)4817-4824
Number of pages8
JournalAdvanced Synthesis and Catalysis
Volume361
Issue number20
DOIs
Publication statusPublished - 2019 Oct 22

Keywords

  • Amides
  • Amine
  • Hydrosilane
  • Nanoporous gold
  • Reduction

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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