Hetero-nanocomposites of magnetic and antifungal nanoparticles as a platform for magnetomechanical stress induction in Saccharomyces cerevisiae

K. Giannousi, M. Menelaou, J. Arvanitidis, M. Angelakeris, A. Pantazaki, C. Dendrinou-Samara

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    Copper(i) oxide (Cu2O) nanoparticles (NPs) of 30 nm with antifungal properties have been functionalized with 9 nm nickel ferrite (NiFe2O4) magnetic nanoparticles (MNPs) to construct hetero-nanocomposites (NCs) of a submicron hydrodynamic size for magnetomechanical stress induction in the yeast, Saccharomyces cerevisiae. A post-synthetic approach involving the assembly through hydrophobic interactions of the preformed NPs of non-uniform sizes, albeit coated with the same surfactant (oleylamine), is reported. Solvents of different polarity were implemented during the synthetic procedure resulting in NCs of similar composition consisting mainly of MNPs randomly decorated onto the bigger Cu2O NPs. The antifungal properties of the building NPs and the NCs were studied in terms of fungistatic and fungicidal activity, whereas the ionic leaching was found to be negligible, highlighting the nanosize effect. Although S. cerevisiae cells were found to be resistant to individual NiFe2O4 MNPs because of their small size, their sensitivity to NCs significantly increased upon short-time exposure to a rotating low-frequency magnetic field (10 min, 30 Hz, 35 G) and this arises from the collective properties. The magnetomechanical cell stress induction was accompanied by alteration of cellular membrane integrity and programmed cell death signaling.

    Original languageEnglish
    Pages (from-to)5341-5351
    Number of pages11
    JournalJournal of Materials Chemistry B
    Volume3
    Issue number26
    DOIs
    Publication statusPublished - 2015 Jul 14

    ASJC Scopus subject areas

    • Chemistry(all)
    • Biomedical Engineering
    • Materials Science(all)

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