Hereditary c8α-γ deficiency associated with dwarfism in the rabbit

M. Komatsu, K. Imaoka, M. Satoh, H. Mikami

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4 Citations (Scopus)


Rabbits deficient in C8α-γ (C8D) were examined for physiological characteristics and linkage relationships. All the C8D rabbits (more than 180 animals obtained thus far) were consistently smaller than normal littermates from birth to adulthood, i.e., 86% of normal size at birth, 57% of normal size at 35 days of age, and 68% of normal size at adulthood. Thus, the C8α-γ deficiency in rabbits is always associated with dwarfism. Furthermore, there appears to be a discrete recessive dwarf gene (dw-2), whose locus is not linked to that of C8D. Rabbits double-homozygous for C8D and dw-2 (severe dwarf) were smaller than the C8D or dwarf rabbits. The segregation of C8D and severe dwarf rabbits in the F2 and backcross offspring was not distorted at birth. However, almost all of the severe dwarf rabbits died within 35 days after birth. The actual and relative weights of the thymus in the C8D rabbits were consistently lower than those of normal rabbits, but histological examination of the C8D thymus did not reveal any abnormalities. Adult C8D rabbits did not produce serum antinuclear antibodies. The C8D and dwarf rabbits were fertile; however, crosses of C8D females with C8D or dwarf males led to a reduced delivery rate and small litter size. The C8D locus is loosely linked to the C3 hypocomplementemic locus (C3-hypo) (map distance 24 cM) but not to the Hg blood group locus.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalJournal of Heredity
Issue number6
Publication statusPublished - 1990 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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