Hemodynamic and metabolic changes during exercise in calves with total artificial hearts of different sizes yet similar output

Keiji Kamohara, Stephan Weber, Ryan S. Klatte, Viviane Luangphakdy, Christine R. Flick, Yoshio Ootaki, Masatoshi Akiyama, Faruk Cingoz, Chiyo Ootaki, Michael W. Kopcak, Jenny Liu, Ji Feng Chen, Jose L. Navia, William A. Smith, Kiyotaka Fukamachi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

To evaluate the effects of downsizing of the total artificial heart (TAH), we compared the anaerobic threshold (AT) values in calves with two different types of TAH (Cleveland Clinic-Nimbus TAH and the downsized MagScrew TAH). Exercise studies were performed using a treadmill in 12 calves. During the exercise, parameters to obtain the AT were measured. To evaluate the determinants of the AT, a linear regression analysis was performed between AT and potential variables. AT values from 29 studies revealed no significant differences between the two different TAHs, with no significant differences in hemodynamic or oxygen metabolic parameters. AT values correlated well with pump flow/body weight (Q) multiplied by the hemoglobin level, regardless of the TAH used. In conclusion, downsizing of the original TAH design did not reduce AT without any significant differences in hemodynamic or oxygen metabolic parameters during exercise in calves.

Original languageEnglish
Pages (from-to)667-676
Number of pages10
JournalArtificial Organs
Volume31
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1
Externally publishedYes

Keywords

  • Anaerobic threshold
  • Animal model
  • Exercise capacity
  • Exercise study
  • Pump downsizing
  • Total artificial heart

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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  • Cite this

    Kamohara, K., Weber, S., Klatte, R. S., Luangphakdy, V., Flick, C. R., Ootaki, Y., Akiyama, M., Cingoz, F., Ootaki, C., Kopcak, M. W., Liu, J., Chen, J. F., Navia, J. L., Smith, W. A., & Fukamachi, K. (2007). Hemodynamic and metabolic changes during exercise in calves with total artificial hearts of different sizes yet similar output. Artificial Organs, 31(9), 667-676. https://doi.org/10.1111/j.1525-1594.2007.00445.x