Hemodynamic analysis of microcirculation in malaria infection

Hitoshi Kondo, Yohsuke Imai, Takuji Ishikawa, Ken Ichi Tsubota, Takami Yamaguchi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Malaria-infected red blood cells (IRBCs) show various changes in mechanical properties. IRBCs lose their deformability and develop properties of cytoadherence and rosetting. To clarify how these changes advance microvascular occlusion, we need qualitative and quantitative information on hemodynamics in malaria infection, including the interaction among IRBCs, healthy RBCs, and endothelial cells. We developed a numerical model of blood flow with IRBCs based on conservation laws of fluid dynamics. The deformability and adhesive property of IRBCs were simply modeled using springs governed by Hook's law. Our model could express the basic behavior of IRBCs, including the rolling motion due to cytoadhesive interaction with endothelial cells and complex interaction with healthy RBCs. We confirmed that these types of interactions significantly increase the flow resistance, particularly when knobs develop.

Original languageEnglish
Pages (from-to)702-709
Number of pages8
JournalAnnals of Biomedical Engineering
Volume37
Issue number4
DOIs
Publication statusPublished - 2009 Apr 1

Keywords

  • Blood flow
  • Computational fluid dynamics
  • Infectious disease
  • Malaria
  • Red blood cell

ASJC Scopus subject areas

  • Biomedical Engineering

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