Hemodynamic analysis of intracranial aneurysms with atherosclerosis

Shinichiro Sugiyama, K. Funamoto, T. Nakayama, K. Niizuma, T. Tominaga

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


Intracranial aneurysms can have atherosclerotic wall properties that may be important in predicting aneurysm history. This study aimed to investigate hemodynamic characteristics of atherosclerotic legions in intracranial aneurysms. We conducted computational fluid dynamic analyses of 30 aneurysms using patient-derived geometries and inlet flow rates. Among 30 aneurysms, seven atherosclerotic lesions with remarkable yellow lipid deposition were identified in five aneurysms. All seven atherosclerotic lesions were spatially agreed with the area exposed to stagnant blood flow. Univariate analysis revealed that male (P = 0.031), cigarette smoking (P = 0.047) and the exposure to stagnant blood flow (P = 0.024) are significantly related to atherosclerotic lesion formation on the aneurysmal wall. Of those variables that influenced atherogenesis, the variable male (P = 0.0046) and the exposure to stagnant flow (P = 0.0037) remained significant in the multivariate regression model. In conclusion, male sex and stagnant blood flow inside aneurysms were independent risk factors for atherosclerosis in intracranial aneurysms.

Original languageEnglish
Title of host publicationThe 15th International Conference on Biomedical Engineering, ICBME 2013
EditorsJames Goh
PublisherSpringer Verlag
Number of pages3
ISBN (Electronic)9783319029122
Publication statusPublished - 2014
Event15th International Conference on Biomedical Engineering, ICBME 2013 - Singapore, Singapore
Duration: 2013 Dec 42013 Dec 7

Publication series

NameIFMBE Proceedings
ISSN (Print)1680-0737


Other15th International Conference on Biomedical Engineering, ICBME 2013


  • Cerebral aneurysm
  • Hemodynamics
  • Stagnation
  • Wall shear stress

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering


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