TY - JOUR
T1 - Heme catabolism and heme oxygenase in neurodegenerative disease
AU - Takeda, Atsushi
AU - Itoyama, Yasuto
AU - Kimpara, Teiko
AU - Zhu, Xiongwei
AU - Avila, Jesús
AU - Dwyer, Barney E.
AU - Perry, George
AU - Smith, Mark A.
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Heme oxygenase, the rate-limiting step in heme catabolism, appears to play an important role in a number of neurodegenerative disorders, such as Alzheimer disease. Interestingly, the spatial distribution of heme oxygenase-1 expression in diseased brain is essentially identical to that of the pathological expression of tau, suggesting a key role for both in disease progression. Like heme oxygenase, the expression, phosphorylation, and aggregation of tau are regulated through signal cascades, including the extracellular signal-regulated kinases, whose activities are modulated by oxidative stress. Therefore, the expression of tau and heme oxygenase-1 in a coordinated manner likely plays a pivotal role in the cytoprotection of neuronal cells. This places heme oxygenase at the center of disease pathogenesis and offers a novel therapeutic approach targeted at either the causes or consequences of enzyme induction.
AB - Heme oxygenase, the rate-limiting step in heme catabolism, appears to play an important role in a number of neurodegenerative disorders, such as Alzheimer disease. Interestingly, the spatial distribution of heme oxygenase-1 expression in diseased brain is essentially identical to that of the pathological expression of tau, suggesting a key role for both in disease progression. Like heme oxygenase, the expression, phosphorylation, and aggregation of tau are regulated through signal cascades, including the extracellular signal-regulated kinases, whose activities are modulated by oxidative stress. Therefore, the expression of tau and heme oxygenase-1 in a coordinated manner likely plays a pivotal role in the cytoprotection of neuronal cells. This places heme oxygenase at the center of disease pathogenesis and offers a novel therapeutic approach targeted at either the causes or consequences of enzyme induction.
UR - http://www.scopus.com/inward/record.url?scp=4544273847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4544273847&partnerID=8YFLogxK
U2 - 10.1089/ars.2004.6.888
DO - 10.1089/ars.2004.6.888
M3 - Review article
C2 - 15345149
AN - SCOPUS:4544273847
VL - 6
SP - 888
EP - 894
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
SN - 1523-0864
IS - 5
ER -