TY - JOUR
T1 - Height, urban-born and prostate cancer risk in Japanese men
AU - Minami, Yuko
AU - Tochigi, Tatsuo
AU - Kawamura, Sadafumi
AU - Tateno, Hiroo
AU - Hoshi, Shigeko
AU - Nishino, Yoshikazu
AU - Kuwahara, Masaaki
N1 - Funding Information:
The authors are grateful to all staff members of the Miyagi Cancer Center who generously cooperated in this study. Support for the study came in part from a Grant-in-Aid for the Second Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labour and Welfare, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan.
PY - 2008/3
Y1 - 2008/3
N2 - Background: Height and early-life environments have received attention as risk factors for prostate cancer. However, the evidence is sparse in Japan. To elucidate the associations of height and early-life factors with prostate cancer risk in Japanese men, we conducted a hospital-based case-control study. In addition, to investigate whether the associations vary between prostate cancer and other major cancers, we conducted a comparative study within the same case-control study. Methods: Study subjects consisted of 282 prostate cancer cases, 584, 461, 231, and 156 male stomach, lung, colon and rectal cancer cases, respectively, and 1730 male hospital controls, aged 50 and over admitted to a single hospital in Miyagi Prefecture from 1997 to 2003. Information on height and early-life factors including birthplace and stature at 12 years was collected using a self-administered questionnaire. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated for each exposure variable. Results: A significant positive association was found between height and prostate cancer risk (OR, 1.52; 95% CI, 1.00-2.31, between the highest and lowest quartiles; P for trend = 0.03). A significant association of urban-born with prostate cancer risk was also found (OR, 1.48; 95% CI, 1.03-2.13). Analyses by stage revealed that height might be more strongly associated with the risk of advanced prostate cancer. For other major cancers, no significant association with height and early-life factors was observed. Conclusions: Height and early-life factors were significantly associated with prostate cancer risk. Compared with other major cancers, these associations were specific to prostate cancer.
AB - Background: Height and early-life environments have received attention as risk factors for prostate cancer. However, the evidence is sparse in Japan. To elucidate the associations of height and early-life factors with prostate cancer risk in Japanese men, we conducted a hospital-based case-control study. In addition, to investigate whether the associations vary between prostate cancer and other major cancers, we conducted a comparative study within the same case-control study. Methods: Study subjects consisted of 282 prostate cancer cases, 584, 461, 231, and 156 male stomach, lung, colon and rectal cancer cases, respectively, and 1730 male hospital controls, aged 50 and over admitted to a single hospital in Miyagi Prefecture from 1997 to 2003. Information on height and early-life factors including birthplace and stature at 12 years was collected using a self-administered questionnaire. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated for each exposure variable. Results: A significant positive association was found between height and prostate cancer risk (OR, 1.52; 95% CI, 1.00-2.31, between the highest and lowest quartiles; P for trend = 0.03). A significant association of urban-born with prostate cancer risk was also found (OR, 1.48; 95% CI, 1.03-2.13). Analyses by stage revealed that height might be more strongly associated with the risk of advanced prostate cancer. For other major cancers, no significant association with height and early-life factors was observed. Conclusions: Height and early-life factors were significantly associated with prostate cancer risk. Compared with other major cancers, these associations were specific to prostate cancer.
KW - Case-control study
KW - Growth
KW - Height
KW - Japanese
KW - Prostate cancer
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U2 - 10.1093/jjco/hym170
DO - 10.1093/jjco/hym170
M3 - Article
C2 - 18272473
AN - SCOPUS:40749142830
VL - 38
SP - 205
EP - 213
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
SN - 0368-2811
IS - 3
ER -