Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs

Hiromu Tanimoto, Susumu Itoh, Peter Ten Dijke, Tetsuya Tabata

Research output: Contribution to journalArticlepeer-review

287 Citations (Scopus)

Abstract

Hedgehog (HH) and Decapentaplegic (DPP) direct anteroposterior patterning in the developing Drosophila wing by functioning as short- and long-range morphogens, respectively. Here, we show that the activity of DPP is graded and is directly regulated by a novel HH-dependent mechanism. DPP activity was monitored by visualizing the activated form of Mothers against dpp (MAD), a cytoplasmic transducer of DPP signaling. We found that activated MAD levels are highest near the source of DPP but are unexpectedly low in the cells that express dpp. HH induces dpp in these cells; it also attenuates their response to DPP by downregulating expression of the DPP receptor thick veins (tkv). We suggest that regulation of tkv by HH is a key part of the mechanism that controls the level and distribution of DPP.

Original languageEnglish
Pages (from-to)59-71
Number of pages13
JournalMolecular Cell
Volume5
Issue number1
DOIs
Publication statusPublished - 2000 Jan

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs'. Together they form a unique fingerprint.

Cite this