TY - JOUR
T1 - Heat-Induced Flower Nanogels of Both Cholesterol End-Capped Poly(N-isopropylacrylamide)s in Water
AU - Morimoto, Nobuyuki
AU - Segui, Florence
AU - Qiu, Xing Ping
AU - Akiyoshi, Kazunari
AU - Winnik, Françoise M.
N1 - Funding Information:
This work is dedicated to the late Professor Françoise M. Winnik, our attentive mentor and a dedicated scientist. N.M. acknowledges financial support from the Japan Society for the Promotion of Science (JSPS) (JP19H03880).
Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Thermoresponsive self-assembled nanogels were conveniently prepared by cholesterol end-capped poly(N-isopropylacrylamide) (PNIPAM) in water. Both cholesterol end-capped PNIPAMs (telelchelic cholesterol PNIPAM, tCH-PNIPAM) formed flower-like nanogels by the self-assembling of four to five polymer chains with multiple domains of cholesterol in water at 20 °C. Meanwhile, one end-group cholesterol-capped PNIPAM (semitelechelic cholesterol PNIPAM, stCH-PNIPAM) was also formed as a nanogel by the self-assembling of 15-20 polymer chains with 3 to 4 cholesterol domains. The hydrophobic cholesterol domains of tCH-PNIPAM nanogels were maintained above the lower critical solution temperature (LCST) of PNIPAM (>32 °C). Differently, the hydrophobic domains of stCH-PNIPAM were disrupted by cholesterol-free PNIPAM chain ends and formed large mesoglobules above the LCST. These transition controls of hydrophilic end-capped smart polymers may open new methodologies to design thermoresponsive nanosystems.
AB - Thermoresponsive self-assembled nanogels were conveniently prepared by cholesterol end-capped poly(N-isopropylacrylamide) (PNIPAM) in water. Both cholesterol end-capped PNIPAMs (telelchelic cholesterol PNIPAM, tCH-PNIPAM) formed flower-like nanogels by the self-assembling of four to five polymer chains with multiple domains of cholesterol in water at 20 °C. Meanwhile, one end-group cholesterol-capped PNIPAM (semitelechelic cholesterol PNIPAM, stCH-PNIPAM) was also formed as a nanogel by the self-assembling of 15-20 polymer chains with 3 to 4 cholesterol domains. The hydrophobic cholesterol domains of tCH-PNIPAM nanogels were maintained above the lower critical solution temperature (LCST) of PNIPAM (>32 °C). Differently, the hydrophobic domains of stCH-PNIPAM were disrupted by cholesterol-free PNIPAM chain ends and formed large mesoglobules above the LCST. These transition controls of hydrophilic end-capped smart polymers may open new methodologies to design thermoresponsive nanosystems.
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U2 - 10.1021/acs.langmuir.1c02394
DO - 10.1021/acs.langmuir.1c02394
M3 - Article
AN - SCOPUS:85119047576
JO - Langmuir
JF - Langmuir
SN - 0743-7463
ER -