Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143

Kota Y. Miyasaka, Yasuyuki S. Kida, Toshihiro Banjo, Yosuke Ueki, Kazuaki Nagayama, Takeo Matsumoto, Masaaki Sato, Toshihiko Ogura

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Cardiogenesis proceeds with concomitant changes in hemodynamics to accommodate the circulatory demands of developing organs and tissues. In adults, circulatory adaptation is critical for the homeostatic regulation of blood circulation. In these hemodynamics-dependent processes of morphogenesis and adaptation, a mechanotransduction pathway, which converts mechanical stimuli into biological outputs, plays an essential role, although its molecular nature is largely unknown. Here, we report that expression of zebrafish miR-143 is dependent on heartbeat. Knocking-down miR-143 results in de-repression of retinoic acid signaling, and produces abnormalities in the outflow tracts and ventricles. Our data uncover a novel epigenetic link between heartbeat and cardiac development, with miR-143 as an essential component of the mechanotransduction cascade.

Original languageEnglish
Pages (from-to)18-28
Number of pages11
JournalMechanisms of Development
Volume128
Issue number1-2
DOIs
Publication statusPublished - 2011 Jan

Keywords

  • Cardiogenesis
  • Heartbeat
  • Hemodynamics
  • Mechano-transduction
  • MiRNA
  • Retinoic acid
  • Zebrafish

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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