Health-related quality of life in Japanese children with acute lymphoblastic leukemia during and after chemotherapy

Kyoko Kobayashi, Etsuko Nakagami-Yamaguchi, Akira Hayakawa, Souichi Adachi, Junichi Hara, Sadao Tokimasa, Hideaki Ohta, Yoshiko Hashii, Takeshi Rikiishi, Machiko Sawada, Kikuko Kuriyama, Urara Kohdera, Kiyoko Kamibeppu, Hirohide Kawasaki, Megumi Oda, Hiroki Hori

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: Quality of life (QOL) as a treatment outcome has not yet been evaluated among patients receiving a specific treatment regimen by treatment phase in a consistent manner. This exploratory cross-sectional study evaluated the QOL of children with acute lymphoblastic leukemia (ALL) receiving one of the most popular treatment regimens in Japan (Japan Association of Childhood Leukemia Study ALL-02 revised protocol). Methods: Children aged 5–18 years with newly diagnosed B-cell precursor ALL were included. The Pediatric Quality of Life Inventory 4.0 Generic Core Scales (PedsQL-J) were completed by children with ALL and their siblings, as well as by age- and sex-matched healthy controls. PedsQL Cancer Module (PedsQL-C) scores were also collected from children with ALL. Results: QOL in children with ALL of the consolidation phase group was significantly decreased compared with that of healthy controls, except in the area of emotional functioning. Regarding the maintenance phase group, QOL impairment was noted in the physical and school functioning, but no differences were noted in social functioning. The off-treatment group had a large effect size only for physical functioning, and the social functioning score was even better in children with ALL than in matched controls. QOL of children with ALL differed with treatment phase. Effect size varied with function and treatment phase. Conclusions: QOL may change with the progression of treatment, and the timing of these changes varied according to function and problem.

Original languageEnglish
Pages (from-to)145-153
Number of pages9
JournalPediatrics International
Issue number2
Publication statusPublished - 2017 Feb 1


  • Japan
  • acute lymphoblastic leukemia
  • cancer treatment protocol
  • pediatrics
  • quality of life

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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