Has widespread use of biologic and immunosuppressant therapy for ulcerative colitis affected surgical trends? Results of a questionnaire survey of surgical institutions in Japan

Hideaki Kimura, Kenichi Takahashi, Kitaro Futami, Hiroki Ikeuchi, Kenji Tatsumi, Kazuhiro Watanabe, Kiyoshi Maeda, Yusuke Watadani, Riichiro Nezu, Hitoshi Kameyama, Sayumi Nakao, Kiyotaka Kurachi, Masayuki Hotokezaka, Koki Otsuka, Toshiaki Watanabe, Heita Ozawa

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Purpose: The aim of the study is to assess the relationship between the introduction of biologic and immunosuppressant therapy and the number of patients undergoing surgery for ulcerative colitis (UC). Methods: A questionnaire survey about patients undergoing surgery for UC was sent to 26 teaching hospitals throughout Japan. The questionnaire period spanned from 2008 to 2013, to account for the introduction of tacrolimus (2009) and infliximab (2010). Results: The total number of patients who underwent surgery was 297, 291, 273, 255, 300, and 305 in 2008, 2009, 2010, 2011 2012, and 2013, respectively. The emergency surgery rate remained stable at 32–34 % each year. The proportion of patients who underwent surgery for cancer increased from 13.8 % in 2008 to 20 % in 2013. In 2013, 41, 38, and 6 % of patients who underwent surgery had received treatment with a biologic, tacrolimus, and cyclosporine, respectively. No institution reported an increase in postoperative complications among patients treated with immunosuppressive drugs. Conclusions: The number of patients undergoing surgery decreased temporarily soon after infliximab and tacrolimus first became widely available, but subsequently increased again. The emergency surgery rate remained unchanged throughout the study period. These data show that immunosuppressive drugs have had little effect on the risk of postoperative complications.

Original languageEnglish
Pages (from-to)930-938
Number of pages9
JournalSurgery today
Volume46
Issue number8
DOIs
Publication statusPublished - 2016 Aug 1

Keywords

  • Biologics
  • Immunosuppressants
  • Surgery
  • Ulcerative colitis

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Has widespread use of biologic and immunosuppressant therapy for ulcerative colitis affected surgical trends? Results of a questionnaire survey of surgical institutions in Japan'. Together they form a unique fingerprint.

Cite this