Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications

Torsten Wagner, Roberto Molina, Tatsuo Yoshinobu, Joachim P. Kloock, Manfred Biselli, Michelangelo Canzoneri, Thomas Schnitzler, Michael J. Schöning

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

The light-addressable potentiometric sensor is a promising technology platform for multi-sensor applications and lab-on-chip devices. However, many prior LAPS developments suffer from their lack in terms of non-portability, insufficient robustness, complicate handling, etc. Hence, portable and robust LAPS-based measurement devices have been investigated by the authors recently. In this work, a "chip card"-based light-addressable potentiometric sensor system is presented. The utilisation of ordinary "chip cards" allows an easy handling of different sensor chips for a wide range of possible applications. The integration of the electronic and the mechanical set-up into a single reader unit results in a compact design with the benefits of portability and low required space. In addition, the presented work includes a new multi-frequency measurement procedure, based on an FFT algorithm, which enables the simultaneous real-time measurement of up to 16 sensor spots. The comparison between the former batch-LAPS and the new FFT-based LAPS set-up will be presented. The immobilisation of biological cells (CHO: Chinese hamster ovary) demonstrates the possibility to record their metabolic activity with 16 measurement spots on the same chip. Furthermore, a Cd2+-selective chalcogenide-glass layer together with a pH-sensitive Ta2O5 layer validates the use of the LAPS for chemical multi-sensor applications.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalElectrochimica Acta
Volume53
Issue number2
DOIs
Publication statusPublished - 2007 Dec 1

Keywords

  • FFT
  • LAPS
  • Light-addressable potentiometric sensor
  • Metabolic activity
  • Multi-sensor

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Electrochemistry

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