Halothane increases the open probability of glycine-activated channel current in rat central neurones

M. Wakamori, Y. Ikemoto, M. Yamashita

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Glycine-activated single-channel currents in rat central neurones were recorded using the outside-out mode of the patch-clamp technique. The unitary conductance of the current was 21 pS. The current evoked by 10 μM glycine had a mean burst duration of 47.8 (2.6) ms and open probability of 0.09 (0.016). Halothane (1 mM) increased the open probability to 0.19 (0.03) without changing either unitary conductance or burst duration. These results suggest that halothane increased the open probability via an increase in the affinity of the receptor for the agonist. Potentiation of the glycine response may reduce excitability of postsynaptic neurones and may contribute to general anaesthesia produced by volatile agents.

Original languageEnglish
Pages (from-to)840-842
Number of pages3
JournalBritish Journal of Anaesthesia
Volume80
Issue number6
DOIs
Publication statusPublished - 1998 Jan 1
Externally publishedYes

Keywords

  • Anaesthetics volatile halothane
  • Channels neurotransmitter-activated
  • Rat
  • Receptors amino acid
  • Theories of anaesthetic action lipid bilayer

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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