Gymnocin-A carboxylic acid and gymnocin-A2, cytotoxic polyethers from the red tide dinoflagellate Karenia mikimotoi

Yoshihisa Tanaka, Masayuki Satake, Mari Yotsu-Yamashita, Yasukatsu Oshima

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Gymnocins are a series of cytotoxic polyether compounds isolated from the notorious red tide dinoflagellate Karenia (formerly Gymnodinium) mikimotoi. Among them, the structures of gymnocin-A and gymnocin-B have already been elucidated. Gymnocin-A carboxylic acid and a new analog of gymnocin-A, gymnocin-A2, were isolated from K. mikimotoi cells, and their structures were determined by detailed analysis of 2D-NMR spectra. The structural changes of gymnocin-A carboxylic acid and gymnocin-A2 occurred on the terminal side chain and ring A in gymnocin-A. Gymnocin-A carboxylic acid and gymnocin-A2 showed moderate cytotoxicity against P388 cells.

Original languageEnglish
Pages (from-to)2037-2046
Number of pages10
JournalHeterocycles
Volume87
Issue number10
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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