TY - JOUR
T1 - Gut Microbiome and Colon Cancer
T2 - Role of Bacterial Metabolites and Their Molecular Targets in the Host
AU - Bhutia, Yangzom D.
AU - Ogura, Jiro
AU - Sivaprakasam, Sathish
AU - Ganapathy, Vadivel
N1 - Funding Information:
This work was supported by the National Institutes of Health, Grant No. CA190710, and by the Welch Endowed Chair in Biochemistry, Grant No. BI-0028, at the Texas Tech University Health Sciences Center.
Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Purpose of Review: The relationship between colonic bacteria and the host is symbiotic, but how communication between the two partners occurs is just beginning to be understood at the molecular level. Here, we highlight specific products of bacterial metabolism that are present in the colonic lumen and their molecular targets in the host that facilitate this communication. Recent Findings: Colonic epithelial cells and mucosal immune cells express several cell surface receptors and nuclear receptors that are activated by specific bacterial metabolites, which impact multiple signaling pathways and expression of many genes. In addition, some bacterial metabolites also possess the ability to cause epigenetic changes in these cells via inhibition of selective enzymes involved in the maintenance of histone acetylation and DNA methylation patterns. Summary: Colonic bacteria communicate with their host with selective metabolites that interact with host molecular targets. This chemical communication underlies a broad range of the biology and function of colonic epithelial cells and mucosal immune cells, which protect against inflammation and carcinogenesis in the colon under normal physiological conditions.
AB - Purpose of Review: The relationship between colonic bacteria and the host is symbiotic, but how communication between the two partners occurs is just beginning to be understood at the molecular level. Here, we highlight specific products of bacterial metabolism that are present in the colonic lumen and their molecular targets in the host that facilitate this communication. Recent Findings: Colonic epithelial cells and mucosal immune cells express several cell surface receptors and nuclear receptors that are activated by specific bacterial metabolites, which impact multiple signaling pathways and expression of many genes. In addition, some bacterial metabolites also possess the ability to cause epigenetic changes in these cells via inhibition of selective enzymes involved in the maintenance of histone acetylation and DNA methylation patterns. Summary: Colonic bacteria communicate with their host with selective metabolites that interact with host molecular targets. This chemical communication underlies a broad range of the biology and function of colonic epithelial cells and mucosal immune cells, which protect against inflammation and carcinogenesis in the colon under normal physiological conditions.
KW - Bacteria-host symbiosis
KW - Bacterial metabolites
KW - Cell surface receptors
KW - Colon cancer
KW - Colonic inflammation
KW - Epigenetics
KW - HIF1α-prolylhydroxylases
KW - Histone deacetylases
KW - NDRG3
KW - Nuclear receptors
KW - TET DNA demethylases
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U2 - 10.1007/s11888-017-0362-9
DO - 10.1007/s11888-017-0362-9
M3 - Review article
AN - SCOPUS:85013427506
VL - 13
SP - 111
EP - 118
JO - Current Colorectal Cancer Reports
JF - Current Colorectal Cancer Reports
SN - 1556-3790
IS - 2
ER -
