Growth of intracranial aneurysms arised from curved vessels under the influence of elevated wall shear stress - A computer simulation study

Yixiang Feng, Shigeo Wada, Ken ichi Tsubota, Takami Yamaguchi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Recent studies have suggested that long standing elevated wall shear stress might degenerate the arterial wall and be involved in the pathogenesis of intracranial aneurysm formation and development. The present study focuses on the interplay between the hemodynamic stresses, arterial wall degeneration and deformation. By constructing a computational model and examining the hypotheses that govern the rules to grow an intracranial aneurysm, we simulate the formation and development of intracranial aneurysms. The high wall shear stress is found to propagate towards the proximal and distal end of the formed aneurysm, which becomes the key factor for the expansion of wall degeneration and aneurysm progression. The development of aneurysm is influenced by the wall shear stress threshold, the Reynolds number and the rate of wall degeneration. Our preliminary results indicate that computer simulation can be used in the study of aneurysm mechanics and yields new insight into the mechanism of aneurysm pathophysiology.

Original languageEnglish
Pages (from-to)1035-1042
Number of pages8
JournalJSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing
Volume47
Issue number4
DOIs
Publication statusPublished - 2004 Dec

Keywords

  • Biomechanics
  • Blood flow
  • Computer aided analysis
  • Computer simulation
  • Intracranial aneurysm
  • Material properties
  • Modeling
  • Progression
  • Wall shear stress

ASJC Scopus subject areas

  • Mechanical Engineering
  • Industrial and Manufacturing Engineering

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