TY - JOUR
T1 - Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26
AU - Endo, Ryo
AU - Ohtsubo, Yoshiyuki
AU - Tsuda, Masataka
AU - Nagata, Yuji
N1 - Funding Information:
This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Agriculture, Forestry, and Fisheries (HC-06-2323) of Japan.
PY - 2006
Y1 - 2006
N2 - The growth of a γ-hexachlorocyclohexane (γ-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by γ-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for γ-HCH degradation, suggesting that metabolites of γ-HCH are toxic to UT26. Two metabolites of γ-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during γ-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.
AB - The growth of a γ-hexachlorocyclohexane (γ-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by γ-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for γ-HCH degradation, suggesting that metabolites of γ-HCH are toxic to UT26. Two metabolites of γ-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during γ-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.
KW - 2,5-dichlorohydroquinone
KW - 2,5-dichlorophenol
KW - Biodegradation
KW - Sphingomonads
KW - γ-hexachlorocyclohexane
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U2 - 10.1271/bbb.70.1029
DO - 10.1271/bbb.70.1029
M3 - Article
C2 - 16636477
AN - SCOPUS:33646149153
VL - 70
SP - 1029
EP - 1032
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 4
ER -