Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26

Ryo Endo; Yoshiyuki Ohtsubo; Masataka Tsuda; Yuji Nagata

doi:10.1271/bbb.70.1029

Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26

Ryo Endo, Yoshiyuki Ohtsubo, Masataka Tsuda, Yuji Nagata

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The growth of a γ-hexachlorocyclohexane (γ-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by γ-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for γ-HCH degradation, suggesting that metabolites of γ-HCH are toxic to UT26. Two metabolites of γ-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during γ-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.

Original language	English
Pages (from-to)	1029-1032
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	70
Issue number	4
DOIs	https://doi.org/10.1271/bbb.70.1029
Publication status	Published - 2006
Externally published	Yes

Keywords

2,5-dichlorohydroquinone
2,5-dichlorophenol
Biodegradation
Sphingomonads
γ-hexachlorocyclohexane

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26",

abstract = "The growth of a γ-hexachlorocyclohexane (γ-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by γ-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for γ-HCH degradation, suggesting that metabolites of γ-HCH are toxic to UT26. Two metabolites of γ-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during γ-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.",

keywords = "2,5-dichlorohydroquinone, 2,5-dichlorophenol, Biodegradation, Sphingomonads, γ-hexachlorocyclohexane",

author = "Ryo Endo and Yoshiyuki Ohtsubo and Masataka Tsuda and Yuji Nagata",

note = "Funding Information: This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Agriculture, Forestry, and Fisheries (HC-06-2323) of Japan.",

year = "2006",

doi = "10.1271/bbb.70.1029",

language = "English",

volume = "70",

pages = "1029--1032",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "4",

}

TY - JOUR

T1 - Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26

AU - Endo, Ryo

AU - Ohtsubo, Yoshiyuki

AU - Tsuda, Masataka

AU - Nagata, Yuji

N1 - Funding Information: This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Agriculture, Forestry, and Fisheries (HC-06-2323) of Japan.

PY - 2006

Y1 - 2006

N2 - The growth of a γ-hexachlorocyclohexane (γ-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by γ-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for γ-HCH degradation, suggesting that metabolites of γ-HCH are toxic to UT26. Two metabolites of γ-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during γ-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.

AB - The growth of a γ-hexachlorocyclohexane (γ-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by γ-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for γ-HCH degradation, suggesting that metabolites of γ-HCH are toxic to UT26. Two metabolites of γ-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during γ-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.

KW - 2,5-dichlorohydroquinone

KW - 2,5-dichlorophenol

KW - Biodegradation

KW - Sphingomonads

KW - γ-hexachlorocyclohexane

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DO - 10.1271/bbb.70.1029

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

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ER -

Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26

Abstract

Keywords

ASJC Scopus subject areas

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