Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26

Ryo Endo, Yoshiyuki Ohtsubo, Masataka Tsuda, Yuji Nagata

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The growth of a γ-hexachlorocyclohexane (γ-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by γ-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for γ-HCH degradation, suggesting that metabolites of γ-HCH are toxic to UT26. Two metabolites of γ-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during γ-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.

Original languageEnglish
Pages (from-to)1029-1032
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume70
Issue number4
DOIs
Publication statusPublished - 2006 May 5

Keywords

  • 2,5-dichlorohydroquinone
  • 2,5-dichlorophenol
  • Biodegradation
  • Sphingomonads
  • γ-hexachlorocyclohexane

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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