Abstract
The growth of a γ-hexachlorocyclohexane (γ-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by γ-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for γ-HCH degradation, suggesting that metabolites of γ-HCH are toxic to UT26. Two metabolites of γ-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during γ-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.
| Original language | English |
|---|---|
| Pages (from-to) | 1029-1032 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 70 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2006 May 5 |
Keywords
- 2,5-dichlorohydroquinone
- 2,5-dichlorophenol
- Biodegradation
- Sphingomonads
- γ-hexachlorocyclohexane
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
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Cite this
Endo, R., Ohtsubo, Y., Tsuda, M., & Nagata, Y. (2006). Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26. Bioscience, Biotechnology and Biochemistry, 70(4), 1029-1032. https://doi.org/10.1271/bbb.70.1029